Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension.
نویسندگان
چکیده
The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS in the adult human brain has been elusive. We demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the OB, and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by magnetic resonance imaging, cell-specific markers, and electron microscopy, contains progenitor cells with migratory characteristics and cells that incorporate 5-bromo-2'-deoxyuridine and become mature neurons in the OB.
منابع مشابه
Comment on "Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension".
Curtis et al. (Research Articles, 2 March 2007, p. 1243) claimed discovery of a human neuronal migratory stream to the olfactory bulb along a putative lateral ventricular extension. However, high levels of proliferation reported with proliferating cell nuclear antigen were not confirmed using different markers, neuronal chain migration was not demonstrated, and no serial reconstruction shows a ...
متن کاملResponse to Comment on “Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension”
In contrast to a previous study of Sanai et al., our study had the advantage of using serial sagittal sections of the human basal forebrain, combined with 5-bromo-2′-deoxyuridine labeling, rigorous magnetic resonance imaging, and polymerase chain reaction analysis. We believe these methods convincingly demonstrate the presence of a rostral migratory stream in the human brain that resembles that...
متن کاملDynamic changes in the transcriptional profile of subventricular zone-derived postnatally born neuroblasts
The subventricular zone (SVZ) of the lateral ventricles is a major neurogenic region in the postnatal mammalian brain. Thousands of neuroblasts are generated daily throughout the life of an animal. Newly born neuroblasts migrate via the rostral migratory stream (RMS) into the olfactory bulb where they mature into distinct neuronal subtypes. Neuroblasts exiting the SVZ retain the ability to prol...
متن کاملDual role for DOCK7 in tangential migration of interneuron precursors in the postnatal forebrain.
Throughout life, stem cells in the ventricular-subventricular zone generate neuroblasts that migrate via the rostral migratory stream (RMS) to the olfactory bulb, where they differentiate into local interneurons. Although progress has been made toward identifying extracellular factors that guide the migration of these cells, little is known about the intracellular mechanisms that govern the dyn...
متن کاملCyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone.
At the lateral wall of the lateral ventricles in the adult rodent brain, neuroblasts form an extensive network of elongated cell aggregates called chains in the subventricular zone and migrate toward the olfactory bulb. The molecular mechanisms regulating this migration of neuroblasts are essentially unknown. Here, we report a novel role for cyclin-dependent kinase 5 (Cdk5), a neuronal protein ...
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ورودعنوان ژورنال:
- Science
دوره 315 5816 شماره
صفحات -
تاریخ انتشار 2007